The rotary drum granulation production line is a large-scale fertilizer production system that realizes the agglomeration of powder or slurry raw materials into granules through an inclined rotating cylinder (rotary drum), widely used in the manufacturing of granular fertilizers such as compound fertilizers, organic fertilizers, and bio-organic fertilizers. The production line consists of a rotary drum granulator, raw material pretreatment equipment, conveying system, dryer, cooler, screening machine, coating machine and packaging equipment. It utilizes the continuous rotation of the drum to make materials roll under the action of gravity, friction and lifting plates in the cylinder, forming uniform granules by adding water or binders. Suitable for medium and large fertilizer production enterprises, a single line can achieve a daily output of 20-100 tons. The produced granules are applicable to various crop planting, meeting the needs of mechanized fertilization and efficient absorption.